Jesstrim Co-trimoxazole 480mg Tablet contains Sulfamethoxazole and Trimethoprim. Sulfamethoxazole competitively inhibits the utilisation of para-aminobenzoic acid in the synthesis of dihydrofolate by the bacterial cell resulting in bacteriostasis. Trimethoprim reversibly inhibits bacterial dihydrofolate reductase (DHFR), an enzyme active in the folate metabolic pathway converting dihydrofolate to tetrahydrofolate. Depending on the conditions the effect may be bactericidal. Thus trimethoprim and sulfamethoxazole block two consecutive steps in the biosynthesis of purines and therefore nucleic acids essential to many bacteria. This action produces marked potentiation of activity in vitro between the two agents.
Jesstrim Co-trimoxazole 480mg Tablet are indicated in adults and children over 12 years for the treatment of the following infections
Each tablet contains
Sulfamethoxazole ...................400mg
Trimethoprim.............................80mg
As prescribed by physician
Store in a dry place below 30°C.
